Part 2

Doom (2016) Part 2 covers the BFG (available Mission 8), Chainsaw (available Mission 2), and enemy details.

Weapons

Gauss Cannon

The most powerful standard weapon, even without mods. Siege Mode is the most powerful mod (by far), and it is strongly recommended. Its challenge upgrade is easy too. The Precision Bolt mod is also pretty good but it's a lot harder to fully upgrade and only kills once thing at a time, so I seldom use it.

BFG (available Mission 8)

The Big F-ing Gun. This will clear out a whole room of demons, but it can be a little unpredictable in how it works. Ammo is found individually, and you always have a limit of 3. However, the Ammo Boost II rune WILL cause enemies to randomly drop BFG ammo when they die so there isn't too much of a shortage.

Chainsaw (available Mission 2)

This crazy melee weapon will definitely kill any monster (except Bosses) in range that you have enough fuel to kill. The initial capacity is 3 Fuel Units, which is the amount in every gas can. Each Argent Cell upgrade to the Ammo Capacity increases your capacity by 1 Fuel. So fully upgraded, you have a capacity of 7 Fuel Units. Killing with a chainsaw is considered a Glory Kill that'll dump a huge pile of ammo.

Fuel to kill various demons:

• Imp: 1
• The Possessed: 1
• Unwilling: 1
• Possessed Guard: 1
• Possessed Securities: 1
• Hell Razer: 1
• Hell Knight: 3
• Summoner: 3
• Cacodaemon: 3
• Pinkie: 3
• Spectre: 3
• Revenant: 3
• Mancubus: 5
• Cyber-Mancubus: 5
• Hell Baron: 5

Weapon Upgrade Path: In My Humble Opinion

Here's how I upgrade my weapons. I usually upgrade one-at-a-time, simply because that spaces the Upgrade Challenges out more.

• Plasma Rifle / Heat Blast
• Rocket Launcher / Lock-On
• Super Shotgun
• Gauss Cannon / Siege Mode
• Assault Rifle / Tactical Scope (Often I get the first two upgrades before Siege Mode is available)
• Pistol
• Rocket Launcher / Remote-Detonation

Monsters

The Possessed, Unwilling

These idiots simply stagger around, vaguely coming toward you. In Nightmare mode, they do quite a bit of damage; in easier modes they are merely pesky.

Imps

Monkeys with fireballs with great aim. You have to move constantly and keep a lookout to avoid getting hit. They can take a fairly large amount of damage when they are climbing around on vertical surfaces. For players in Nightmare mode, Imps will probably cause more deaths than any other demon.

Possessed Engineers

Somewhat like the Possessed, except they explode when they die, and they charge at you to cause trouble. These guys are walking bombs - typically when they die they'll fly away from you which mitigates the problems. But some weapons might cause them to fly at you, and they'll do moderate damage. Even if you jump from above them and Glory Kill them, it does not count as a Death From Above Glory Kill (at least for the purposes of Rune or Combat Challenges).

Possessed Soldiers and Possessed Securities

These two monsters differ in that the latter has shields. They have 3 attacks: Plasma Volley (an attack of many straight-moving weak plasma baubles), Plasma Grenade (a stronger attack, similar to the Rocket Launcher / Remote Detonation, which expands before blowing up like a bomb), and Melee Attack (these are fairly weak for Possessed Soldiers, but they are quite strong from the shielded soldiers). The shields are a big difficulty: the Gauss Cannon or Chainsaw are the surest ways to kill them - you'll run into them before you have the Gauss Cannon. Otherwise, try running around them (around a structure) or jumping over them. Also they have to put their shields down when they jump/drop.

Hell Razers

These hellions attack with a laser in their arm, or a melee attack. They have a lot of hit-points, but they aren't too hard to kill.

Lost Souls

These little punks are very damaging. It's best to snipe them from afar (effective weapons: Assault Rifle/Tacticle Scope, Rocket Launcher/Lock-On, BFG). At the last moment when they are swooping in on you, the Shotgun or Super-Shotgun is probably the best, if you're quick. They can make little turns, but you can sneak behind pillars or protected areas.

Hell Knights

These are brutal melee attackers. They will jump toward you very fast. It is best to approach them right after an attack (Super Shotgun, Gauss Cannon) then back-off - a kind-of dance, or just use the Chainsaw which'll definitely kill them if you have fuel.

Summoners

These red-dressed ladies fire intense energy beams along the floor. Fortunately, the shot comes with a harmless pre-shot, so if you see a short red flame running along the ground, get away from it. The Rocket Launcher / Lock-On's Multi-Target Upgrade requires 5 kills on Summoners, so if you want to get that upgrade, you'll want to kill every summoner with lock-on rockets. That said, this upgrade isn't particularly useful.

Cacodemons

Big floating eyeballs with gigantic purple missiles. They do have a weak point near their eye opening, and precision shots with the tactical shot of the assault rifle can kill it from afar pretty quickly.

Revenants

These tough lanky flying demons wear a backpack to shoot you from above. They can take a significant amount of damage. The visible patch on the sternum (center of the chest) is a weak point.

Pinkies and Spectres

These are big charging idiot monsters. The Pinkies are substantially heartier. They are literally pink. The Spectres are essentially camoflaged Pinkies. They blend into their surroundings. I suggest using Super Shotgun, Chainsaw, Gauss Cannon on these guys. But really, any weapon will work.