Resident Evil 4 Remake Trophy Guide Roadmap

First Playthrough (Normal Difficulty): Focus on completing the main story, all 19 Requests for the 'Jack of All Trades' trophy, finding all 180 collectibles for 'Bandit', 'Burglar', and 'Raider' trophies, and finding all Clockwork Castellans for the 'Revolution Wind-up' trophy. Also, work towards chapter-specific trophies like 'Minimalist', 'Frugalist', 'Never Heard It Coming', 'Capacity Compliance', and 'You Talk Too Much!'. Specific chapter trophies include 'Overkill' (shoot a zealot with a cannon in Chapter 7), 'Never Heard It Coming' (defeat a Garrador with only knives), 'Capacity Compliance' (reach the top of the clock tower without the lift stopping), 'You Talk Too Much!' (throw a grenade into Ramón Salazar’s mouth), 'Hope You Like Thrill Rides!' (complete minecart sections without damage), and 'Smooth Escape' (escape on the water scooter without damage).

Second Playthrough (New Game+, Assisted Difficulty): Use only Pistols and Knives for the 'Minimalist' trophy. Sell all other weapons and upgrade your chosen pistol and the indestructible Primal Knife (obtained from finding all Clockwork Castellans). Sell all healing items and avoid using them for the 'Frugalist' trophy; health recovers automatically on Assisted difficulty. Purchase the Infinite Rocket Launcher for 2,000,000 Pesetas before this playthrough.

Third Playthrough (New Game+, Professional Difficulty): Complete the game on Professional difficulty while avoiding the Merchant for the 'Silent Stranger' trophy. Aim to beat the game within 8 hours for the 'Sprinter' trophy by skipping cutscenes and utilizing chapter skips.

Fourth Playthrough (Professional Difficulty): Start a fresh playthrough on Professional difficulty to earn the Handcannon and the 'Gun Fanatic' trophy. This playthrough will be more challenging without upgraded weapons or the Rocket Launcher. Equip Leon with the Gas Mask for Aim Assist and Ashley with her armor to reduce revivals. Save regularly and take your time.

Fifth and Sixth Playthroughs (Standard and Hardcore S-Rank): Complete two more full playthroughs, one on Standard and one on Hardcore, achieving an S-Rank on each for the 'Mission Accomplished S+' and 'S+ Rank Investigator' trophies. These must be fresh playthroughs without upgraded weapons, but you can use bonus weapons like the Primal Knife, Chicago Sweeper, and Handcannon. Equip Leon with the Gas Mask and Ashley with her armor. To achieve S-Rank, beat the game within 5 hours by focusing on main objectives and using chapter skips.