BG3 Netherbrain Fight Guide: Tactics, Tips & More

Before reaching the Netherbrain, ensure you have access to powerful spells. Hold Monster can be used on the Emperor or the dragon to grant critical hits to your martial characters. Globe of Invulnerability is excellent for protecting the channeler during Netherstone rituals, ensuring you reach the final phase. Sanctuary is a decent alternative for the channeler, but be wary of splash damage and concentration breaks.

If you have other crowd control (CC) abilities like Mind Blast or Stunning Gaze, use them to stun the dragon, the primary threat, to make it miss turns.

Consider using legendary weapons and armor, though they are not strictly necessary.

If possible, use Voss’s dragon fire to hit at least two Mind Flayers near the crown, as it can deal around 60 HP damage and potentially kill them with movement damage. Alternatively, summon allies near tough enemies to act as action baits.

When the fight begins, be aware of the timer before the Nautiloid arrives. Get into the brain room before it bombards your allies' positions to avoid making battlefield control harder. Spend your first few turns controlling the battlefield and positioning your channeler and damage support. Use summoned allies before the Nautiloid arrives, as they have low HP (around 70 or less) and can be one-shot.

Once inside the brain room, you must hit the Netherbrain for 300 points of damage within 5 turns. Bringing allies into this room is optional.

Focus on dealing damage to the Netherbrain's HP bar. Aim for an average of 60 damage per turn to meet the five-turn timer. High-damage spells, Ki points, Adrenaline Surge actions, and other combos are effective.